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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $141.95 | Total: $709.75 |
| 1 | 10 | $120.24 | Total: $1,202.40 |
| 1 | 25 | $101.87 | Total: $2,546.75 |
| 1 | 50 | $86.84 | Total: $4,342.00 |
| 1 | 100 | $75.15 | Total: $7,515.00 |
Overview
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC.
Chemical Properties
| Molecular Formula | C28H41NO9 |
| Molecular Weight | 535.63 |
| CAS Numbers | 1426953-21-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@H](OC(C)=O)C=CC(=O)N[C@@H]1C[C@H](C)[C@H](CC=C(C)C=C[C@H]2O[C@H](CC(O)=O)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C |
Storage and Handling
0C Short Term, -20C Long Term
References
Puthenveetil S, et al. Natural Product Splicing Inhibitors A New Class of Antibody-Drug Conjugate [ADC] Payloads. Bioconjug Chem. 2016;27[8] 1880-1888.