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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $84.15 | Total: $420.75 |
| 1 | 10 | $71.28 | Total: $712.80 |
| 1 | 25 | $60.39 | Total: $1,509.75 |
| 1 | 50 | $51.48 | Total: $2,574.00 |
| 1 | 100 | $44.55 | Total: $4,455.00 |
Overview
GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 12), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAPTAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].
Chemical Properties
| Molecular Formula | C18H21N3O4 |
| Molecular Weight | 343.38 |
| CAS Numbers | 2351906-74-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCC(=NNC(=O)NCc1cccc(O)c1)c1ccc(O)c(C)c1O |
Storage and Handling
0C Short Term, -20C Long Term
References
Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298[4] 101779.