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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $69.70 | Total: $348.50 |
| 1 | 10 | $59.04 | Total: $590.40 |
| 1 | 25 | $50.02 | Total: $1,250.50 |
| 1 | 50 | $42.64 | Total: $2,132.00 |
| 1 | 100 | $36.90 | Total: $3,690.00 |
Overview
safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin levels, and fibrogenesis as judged by type I and type III collagen and laminin production. safironil had no effect on the size of liver granulomas without altering total hydroxyproline, but altered the pattern of fibrosis by increasing type III and decreasing type I collagen deposition.
Chemical Properties
| Molecular Formula | C15H23N3O4 |
| Molecular Weight | 309.36 |
| CAS Numbers | 134377-69-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(NCCCOC)(=O)C=1C=C(C(NCCCOC)=O)N=CC1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Wang YJ, et al. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury differential effects in males and females. Am J Pathol. 1998;152[1] 279-287.