Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $95.20 | Total: $476.00 |
| 1 | 10 | $80.64 | Total: $806.40 |
| 1 | 25 | $68.32 | Total: $1,708.00 |
| 1 | 50 | $58.24 | Total: $2,912.00 |
| 1 | 100 | $50.40 | Total: $5,040.00 |
Overview
BMS-684 is a selective and potent DGK? inhibitor (IC50: 15 nM) with potential antitumor activity.BMS-684 inhibits DGK? kinase, DGK?, and DGK?.BMS-684 activates T-cells, which may prevent and treat immune-related diseases.
Chemical Properties
| Molecular Formula | C27H26N4O3 |
| Molecular Weight | 454.52 |
| CAS Numbers | 313552-29-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C1C([N+]([O-])=O)=C(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C5=C(N1C)C=CC=C5 |
Storage and Handling
0C Short Term, -20C Long Term
References
Michael Wichroski, et al. DGK?? inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Sci Transl Med. 2023 Oct 25;15[719] eadh1892.