Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $90.95 | Total: $454.75 |
| 1 | 10 | $77.04 | Total: $770.40 |
| 1 | 25 | $65.27 | Total: $1,631.75 |
| 1 | 50 | $55.64 | Total: $2,782.00 |
| 1 | 100 | $48.15 | Total: $4,815.00 |
Overview
BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) ? and ? that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune responses in a dose-dependent manner and can be used to study immune-related diseases.
Chemical Properties
| Molecular Formula | C27H22F2N6O3 |
| Molecular Weight | 516.5 |
| CAS Numbers | 2407854-18-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3)=O)C=C1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14[7] 929-935.