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Tenofovir alafenamide fumarate
AOB10559
CAS: 379270-38-9
Chemical Name: GS-7340 fumarate; Propan-2-yl (2S)-2-[[[(2R)-1-(6-Aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate fumarate
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | 5 mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $29.75 | Total: $148.75 |
| 1 | 10 | $25.20 | Total: $252.00 |
| 1 | 25 | $21.35 | Total: $533.75 |
| 1 | 50 | $18.20 | Total: $910.00 |
| 1 | 100 | $15.75 | Total: $1,575.00 |
Overview
Nucleotide reverse transcriptase inhibitor (NRTI) and a novel prodrug of the antiretroviral tenofovir
Chemical Properties
| Molecular Formula | C25H33N6O9P |
| Molecular Weight | 592.55 |
| CAS Numbers | 379270-38-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | Propan-2-yl (2S)-2-[[[(2R)-1-(6-Aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate fumarate |
| SMILES Code | NC1=NC=NC2=C1N=CN2C[C@@H](C)OC[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O.O=C(O)/C=C/C(O)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
GS-7340 fumarate
References
1) Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66.
2) Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.