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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $117.30 | Total: $586.50 |
| 1 | 10 | $99.36 | Total: $993.60 |
| 1 | 25 | $84.18 | Total: $2,104.50 |
| 1 | 50 | $71.76 | Total: $3,588.00 |
| 1 | 100 | $62.10 | Total: $6,210.00 |
Overview
RMC-6291 is an orally active, covalent inhibitor of KRAS G12C (ON) that forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA), thereby preventing KRAS G12C (ON) from signaling via steric blockade of RAS effector binding and eliciting deep and durable suppression of RAS pathway activity in KRAS G12C tumor models [1].
Chemical Properties
| Molecular Formula | C55H78FN9O8 |
| Molecular Weight | 1012.26 |
| CAS Numbers | 2641998-63-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C(C#CC(N(C)C)(C)C)N1CCC(F)(C(=O)N(C)C(C(=O)NC2C(=O)N3NC(C(=O)OCC(C)(C)CC=4C5=CC(=CC=C5N(C4C=6C=CC=NC6C(OC)C)CC)N7CCOC(C7)C2)CCC3)C(C)C)CC1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Nichols R J, et al. RMC-6291, a next-generation tri-complex KRASG12C [ON] inhibitor, outperforms KRASG12C [OFF] inhibitors in preclinical models of KRASG12C cancers[J]. Cancer Research, 2022, 82[12_Supplement] 3595-3595.