Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
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- Activators
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- Nuclear Receptor Ligands
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $280.50 | Total: $1,402.50 |
| 1 | 10 | $237.60 | Total: $2,376.00 |
| 1 | 25 | $201.30 | Total: $5,032.50 |
| 1 | 50 | $171.60 | Total: $8,580.00 |
| 1 | 100 | $148.50 | Total: $14,850.01 |
Overview
BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research.
Chemical Properties
| Molecular Formula | C30H37N9O2S |
| Molecular Weight | 587.74 |
| CAS Numbers | 2750570-55-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C=4N=C(C=C(C4)N5CCN(C(C=C)=O)CC5)N6[C@@H](C)CN(C)CC6 |
Storage and Handling
0C Short Term, -20C Long Term
References
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