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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $164.90 | Total: $824.50 |
| 1 | 10 | $139.68 | Total: $1,396.80 |
| 1 | 25 | $118.34 | Total: $2,958.50 |
| 1 | 50 | $100.88 | Total: $5,044.00 |
| 1 | 100 | $87.30 | Total: $8,730.00 |
Overview
BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants with an average IC50 value of approximately 140 nM.
Chemical Properties
| Molecular Formula | C23H27N7O2S |
| Molecular Weight | 465.57 |
| CAS Numbers | 2937327-93-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C=4N=C(O[C@@H](C)[C@@]5(CCCN5C)[H])C=CN4 |
Storage and Handling
0C Short Term, -20C Long Term
References
Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023;619[7968] 160-166.