Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
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- Customized Screening Library
- Ultra Pure Pharmacological Standard
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- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $229.50 | Total: $1,147.50 |
| 1 | 10 | $194.40 | Total: $1,944.00 |
| 1 | 25 | $164.70 | Total: $4,117.50 |
| 1 | 50 | $140.40 | Total: $7,020.00 |
| 1 | 100 | $121.50 | Total: $12,150.01 |
Overview
Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades the wild-type androgen receptor AR, as well as AR LBD mutants including those associated with the most prevalent pathogenic AR L702H, H875Y and T878A mutations.
Chemical Properties
| Molecular Formula | C45H54FN7O6 |
| Molecular Weight | 807.95 |
| CAS Numbers | 2750830-09-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O([C@H]1C(C)(C)[C@H](NC(=O)C2=CC=C(C=C2)N3CCC(CN4CCN(CC4)C5=CC(F)=C(C(N[C@@H]6C(=O)NC(=O)CC6)=O)C=C5)CC3)C1(C)C)C7=CC(OC)=C(C#N)C=C7 |
Storage and Handling
0C Short Term, -20C Long Term
References
Petrylak D P, et al. A phase 2 expansion study of ARV-766, a PROTAC androgen receptor [AR] degrader, in metastatic castration-resistant prostate cancer [mCRPC]. 2023.