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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $106.25 | Total: $531.25 |
| 1 | 10 | $90.00 | Total: $900.00 |
| 1 | 25 | $76.25 | Total: $1,906.25 |
| 1 | 50 | $65.00 | Total: $3,250.00 |
| 1 | 100 | $56.25 | Total: $5,625.00 |
Overview
Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ER? degradation).
Chemical Properties
| Molecular Formula | C31H30Cl2FNO3 |
| Molecular Weight | 554.48 |
| CAS Numbers | 2114339-57-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | OC(=O)c1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
El-Ahmad Y, et al. Discovery of 6-[2,4-Dichlorophenyl]-5-[4-[[3S]-1-[3-fluoropropyl]pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid [SAR439859], a Potent and Selective Estrogen Receptor Degrader [SERD] for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J Med Chem. 2019 Nov 27.