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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $63.75 | Total: $318.75 |
| 1 | 10 | $54.00 | Total: $540.00 |
| 1 | 25 | $45.75 | Total: $1,143.75 |
| 1 | 50 | $39.00 | Total: $1,950.00 |
| 1 | 100 | $33.75 | Total: $3,375.00 |
Overview
Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388CPT45 cells as compared with P388 cells.
Chemical Properties
| Molecular Formula | C23H23N3O5 |
| Molecular Weight | 421.45 |
| CAS Numbers | 500214-53-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhou W, Dai Z, Chen Y, Wang H, Yuan Z. High-Dimensional descriptor selection and computational QSAR modeling for antitumor activity of ARC-111 analogues Based on Support Vector Regression [SVR]. Int J Mol Sci. 2012;13[1] 1161-72. doi 10.3390ijms13011161. PubMed PMID 22312310; PubMed Central PMCID PMC3269744.