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Overview
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
Chemical Properties
| Molecular Formula | C18H21ClFN3O4 |
| Molecular Weight | 397.8 |
| CAS Numbers | 177325-13-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Schmitz FJ, et al. J Antimicrob ChemOthers. 1998 Apr;41[4] 481-4.