Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $53.55 | Total: $267.75 |
| 1 | 10 | $45.36 | Total: $453.60 |
| 1 | 25 | $38.43 | Total: $960.75 |
| 1 | 50 | $32.76 | Total: $1,638.00 |
| 1 | 100 | $28.35 | Total: $2,835.00 |
Overview
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1].
Chemical Properties
| Molecular Formula | C29H27F2NO7 |
| Molecular Weight | 539.52 |
| CAS Numbers | 1918142-35-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1ccc2[C@H](C[C@H](Oc2c1)c1ccc(OC)c(OC)c1)NC(=O)C1(CC1)c1ccc2OC(F)(F)Oc2c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Wang X, et al. Discovery of 4-[[2R,4R]-4-[{[1-[2,2-Difluoro-1,3-benzodioxol-5-yl]cyclopropyl]carbonyl}amino]-7-[difluoromethoxy]-3,4-dihydro-2H-chromen-2-yl]benzoic Acid [ABBVGLPG-2222], a Potent Cystic Fibrosis Transmembrane Conductance Regulator [CFTR] Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018;61[4] 1436-1449.