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Overview
2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), activates Nrf2 and S-arylates its negative regulator Keap1 in RAW264.7 cells.
Chemical Properties
| Molecular Formula | C10H12O2 |
| Molecular Weight | 164.2 |
| CAS Numbers | 3602-55-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)(C)C1=CC(=O)C=CC1=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Abiko Y, Kumagai Y. Interaction of Keap1 modified by 2-tert-butyl-1,4-benzoquinone with GSH evidence for S-transarylation. Chem Res Toxicol. 2013 Jul 15;26[7] 1080-7.