Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
MLN7243 (TAK-243)
AOB87172
CAS No:1450833-55-2
Chemical Name: TAK-243; [(1R,2R,3S,4R)-2,3-dihydroxy-4-[[2-[3-[(trifluoromethyl)thio]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]sulfamic acid methyl ester
AOBIOUS launched this product in 2015
CITATIONS - Publications That Use AOBIOUS Product
376 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $28.48 | Total: $142.38 |
| 1 | 10 | $24.12 | Total: $241.20 |
| 1 | 25 | $20.44 | Total: $510.88 |
| 1 | 50 | $17.42 | Total: $871.00 |
| 1 | 100 | $15.08 | Total: $1,507.50 |
Overview
The first-in-class selective inhibitor of ubiquitin-activating enzymes (UAE, also known as E1 enzymes)
Chemical Properties
| Molecular Formula | C19H20F3N5O5S2 |
| Molecular Weight | 519.5 |
| CAS Numbers | 1450833-55-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate |
| InChl Key | PUMGWJMQPGYZFC-IDCJVQTKSA-N |
| InChl Code | InChI=1S/C19H20F3N5O5S2/c1-32-34(30,31)26-14-8-13(17(28)18(14)29)24-15-5-6-23-16-9-12(25-27(15)16)10-3-2-4-11(7-10)33-19(20,21)22/h2-7,9,13-14,17-18,24,26,28-29H,8H2,1H3/t13-,14+,17+,18-/m1/s1 |
| SMILES Code | COS(=O)(=O)N[C@H]1C[C@H]([C@@H]([C@@H]1O)O)NC2=CC=NC3=CC(=NN23)C4=CC(=CC=C4)SC(F)(F)F |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
References
1) Preparation of ubiquitin-activating enzyme inhibitor and use alone and in combination with other chemotherapeutic agents for treatment of cancer by Bence, Neil etc from PCT Int. Appl. (2016), WO 2016069392 A1 20160506.
2) Preparation of ubiquitin-activating enzyme inhibitor and use in combination with radiation for treatment of cancer by Bence, Neil etc from PCT Int. Appl. (2016), WO 2016069393 A1 20160506.
3) Preparation of pyrazolopyrimidinyl compounds as inhibitors of ubiquitin-activating enzyme by Afroze, Roushan etc from PCT Int. Appl. (2013), WO 2013123169 A1 20130822
