Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $72.25 | Total: $361.25 |
| 1 | 10 | $61.20 | Total: $612.00 |
| 1 | 25 | $51.85 | Total: $1,296.25 |
| 1 | 50 | $44.20 | Total: $2,210.00 |
| 1 | 100 | $38.25 | Total: $3,825.00 |
Overview
OTUB1USP8-IN-1 is a potent OTUB1USP8 inhibitor with potential anticancer activity, demonstrating IC50 values of 0.17 nM for OTUB1 and 0.28 nM for USP8. OTUB1USP8-IN-1 can be used in the study of non-small-cell lung cancer.
Chemical Properties
| Molecular Formula | C22H16ClFN2O4 |
| Molecular Weight | 426.83 |
| CAS Numbers | 2858800-98-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C1C2=C(OC(=N2)C3=C(Cl)C(O[C@H]4CN(C)CC4)=CC=C3F)C(=O)C=5C1=CC=CC5 |
Storage and Handling
0C Short Term, -20C Long Term
References
Tan L, et al. Discovery of Potent OTUB1USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem. 2022 Oct 11.