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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $142.80 | Total: $714.00 |
| 1 | 10 | $120.96 | Total: $1,209.60 |
| 1 | 25 | $102.48 | Total: $2,562.00 |
| 1 | 50 | $87.36 | Total: $4,368.00 |
| 1 | 100 | $75.60 | Total: $7,560.00 |
Overview
I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.
Chemical Properties
| Molecular Formula | C26H23F3N6O |
| Molecular Weight | 492.5 |
| CAS Numbers | 2098211-50-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(N1C=2C(NC1=O)=CN=C(N2)C3=C(C(C)C)C=CC=C3)C4=CC=C(C=C4)C5=NC(C(F)(F)F)=CN5C |
Storage and Handling
0C Short Term, -20C Long Term
References
Simoneau A, et al. Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer. Mol Cancer Ther. 2023 Feb 1;22[2] 215-226.