Dasatinib (BMS-354825)

Dasatinib (BMS-354825) Bulk

AOB87355

Chemical Name: Sprycel; BMS-354825; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

More details

998 Items

$50.00

$50.00 per 20mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity20mgUnit Price ($/mg or $/Unit)Final Price
15 $42.50 Total: $212.50
110 $36.00 Total: $360.00
125 $30.50 Total: $762.50
150 $26.00 Total: $1,300.00
1100 $22.50 Total: $2,250.00

Overview

Oral dual BCR/ABL and Src family tyrosine kinase inhibitor

Chemical Properties

Molecular FormulaC22H26ClN7O2S
Molecular Weight488.01
CAS Numbers302962-49-8
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical NameN-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
InChl KeyZBNZXTGUTAYRHI-UHFFFAOYSA-N
InChl Code1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
SMILES CodeCC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCO)=N1

Synonyms

Sprycel; BMS-354825

References

1) Lombardo, L.J., Lee, F.Y., Chen, P., et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825),a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J. Med. Chem. 47(27), 6658-6661 (2004).

2) Das, J., Chen, P., Norris, D., et al. 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J. Med. Chem. 49(23), 6819-6823 (2006).

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