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Rokitamycin
AOB9356
CAS: 74014-51-0
Chemical Name: Ricamycin; Propionylleucomycin; [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-Dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-2,4-dimethyl-4-propanoyloxyoxan-3-yl] butanoate
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $17.85 | Total: $89.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 100 | $9.45 | Total: $945.00 |
Overview
Macrolide antibiotic, inducing DNA fragmentation and caspase activation, resembling the progression of apoptosis, reducing the mitochondrial transmembrane potential and released cytochrome c from mitochondria to the cytosol
References:
https://pubmed.ncbi.nlm.nih.gov/?term=Rokitamycin+&sort=date
Chemical Properties
| Molecular Formula | C42H68NO16 |
| Molecular Weight | 842.99 |
| CAS Numbers | 74014-51-0 |
| Solubility | DMSO and Water |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3-((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(butyryloxy)-6-(((2S,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-3-yl)propanoate |
| InChl Key | WMPXTDMRSHZXNQ-TYEDIMFNSA-M |
| InChl Code | InChI=1S/C42H69NO16/c1-10-14-31(48)57-37-28(17-18-30(46)47)40(51)54-24(3)15-12-11-13-16-29(45)23(2)21-27(19-20-44)36(38(37)53-9)59-41-34(49)33(43(7)8)35(25(4)56-41)58-32-22-42(6,52)39(50)26(5)55-32/h11-13,16,20,23-29,32-39,41,45,49-50,52H,10,14-15,17-19,21-22H2,1-9H3,(H,46,47)/p-1/b12-11+,16-13+/t23-,24-,25-,26+,27+,28?,29+,32+,33-,34-,35-,36+,37-,38+,39+,41+,42-/m1/s1 |
| SMILES Code | O[C@H]([C@@H](N(C)C)[C@@H]([C@@H](C)O1)O[C@H]2C[C@@]([C@H]([C@H](C)O2)O)(C)O)[C@@H]1O[C@@H]3[C@H](OC)[C@H](OC(CCC)=O)C(CCC([O-])=O)C(O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@@H]3CC=O)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Rokitamycin
References
1) Kim JH, Lee YJ, Sohn HJ, Song KJ, Kwon D, Kwon MH, Im KI, Shin HJ. Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri. Int J Antimicrob Agents. 2008 Nov;32(5):411-7. doi: 10.1016/j.ijantimicag.2008.05.018. Epub 2008 Aug 30. PubMed PMID: 18762406.