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L-364373
AOB3049
CAS: 103342-82-1
Chemical Name: R-L3; (R)-L3; (3-R)-1,3-Dihydro-5-(2-fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one
939 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $38.25 | Total: $191.25 |
| 1 | 10 | $32.40 | Total: $324.00 |
| 1 | 25 | $27.45 | Total: $686.25 |
| 1 | 50 | $23.40 | Total: $1,170.00 |
| 1 | 100 | $20.25 | Total: $2,025.00 |
Overview
Potent Kv7.1 KCNQ1 potassium channel activator, activating and slowing the rates of activation and deactivation of hKv7.1 channels expressed in Xenopus oocytes
Chemical Properties
| Molecular Formula | C25H20FN3O |
| Molecular Weight | 397.44 |
| CAS Numbers | 103342-82-1 |
| Solubility | 39.74mg / 1 mL DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (DL)-2-Amino-8-oxononanoic acid hydrochloride |
| InChl Key | CGBANSGENFERAT-JOCHJYFZSA-N |
| SMILES Code | CN(C1=CC=CC=C1C(C5=CC=CC=C5F)=N[C@@H]2CC3=CNC4=C3C=CC=C4)C2=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
References
1) Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941 PMID: 14576198
2) Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443 PMID: 16945016
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