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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $36.55 | Total: $182.75 |
| 1 | 10 | $30.96 | Total: $309.60 |
| 1 | 25 | $26.23 | Total: $655.75 |
| 1 | 50 | $22.36 | Total: $1,118.00 |
| 1 | 100 | $19.35 | Total: $1,935.00 |
Overview
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 ?M, 0.57 ?M, and 0.63 ?M for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury.
Chemical Properties
| Molecular Formula | C17H17N3O |
| Molecular Weight | 279.34 |
| CAS Numbers | 1270084-92-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCCc1c(O)n(nc1-c1ccccc1)-c1ccccn1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8[43] 74217-74232.