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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $85.00 | Total: $425.00 |
| 1 | 10 | $72.00 | Total: $720.00 |
| 1 | 25 | $61.00 | Total: $1,525.00 |
| 1 | 50 | $52.00 | Total: $2,600.00 |
| 1 | 100 | $45.00 | Total: $4,500.00 |
Overview
Pico145 (HC-608) is a remarkable inhibitor of TRPC145 channels, specifically inhibiting ( )-englerin A-activated TRPC4TRPC5 channels with IC50s of 0.349 and 1.3 nM in cells, while showing no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, or TRPM8.
Chemical Properties
| Molecular Formula | C23H20ClF3N4O5 |
| Molecular Weight | 524.88 |
| CAS Numbers | 1628287-16-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cn1c2nc(Oc3cccc(OC(F)(F)F)c3)n(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Rubaiy HN, et al. Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC145 channels. J Biol Chem. 2017 May 19;292[20] 8158-8173.