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AOB8201
CAS No: 878983-38-1
Chemical Name: 1-(4-Chloro-phenyl)-3-[4-(4-trifluoromethoxy-phenylamino)-piperidin-1-yl]-pyrrolidine-2,5-dione
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $9.45 | Total: $945.00 |
1 | 50 | $10.92 | Total: $546.00 |
1 | 25 | $12.81 | Total: $320.25 |
1 | 10 | $15.12 | Total: $151.20 |
1 | 5 | $17.85 | Total: $89.25 |
Molecular Formula | C22H21ClF3N3O3 |
Molecular Weight | 467.87 |
CAS Numbers | 878983-38-1 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO |
Purity | 98% by HPLC |
Synonym | AKOS-22; AKOS 22; AKOS22; AKOS-022075291; AKOS 022075291; AKOS022075291 |
IUPAC/Chemical Name | 1-(4-Chloro-phenyl)-3-[4-(4-trifluoromethoxy-phenylamino)-piperidin-1-yl]-pyrrolidine-2,5-dione |
InChl Key | ZZVCWIMICOFQNJ-UHFFFAOYSA-N |
InChl Code | InChI=1S/C22H21ClF3N3O3/c23-14-1-5-17(6-2-14)29-20(30)13-19(21(29)31)28-11-9-16(10-12-28)27-15-3-7-18(8-4-15)32-22(24,25)26/h1-8,16,19,27H,9-13H2 |
SMILES Code | O=C(C(N1CCC(NC2=CC=C(OC(F)(F)F)C=C2)CC1)C3)N(C4=CC=C(Cl)C=C4)C3=O |
References | Danya Ben-Hail 1 , Racheli Begas-Shvartz 1 , Moran Shalev 1 , Anna Shteinfer-Kuzmine 1 , Arie Gruzman 2 , Simona Reina 3 ,4 , Vito De Pinto 3 and Varda Shoshan-Barmatz 1, * Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondria dysfunction. JBC Papers in Press. Published on October 13, 2016 as Manuscript M116.744284. |
Inhibitor of both VDAC1 oligomerization and apoptosis in a concentration-dependent manner, with 50% inhibition of both apoptosis and VDAC1 oligomerization