Apoptosis

AKOS-22 View larger

AKOS-22

AOB8201

CAS No: 878983-38-1

 

Chemical Name: 1-(4-Chloro-phenyl)-3-[4-(4-trifluoromethoxy-phenylamino)-piperidin-1-yl]-pyrrolidine-2,5-dione

More details

Molarity Calculation Cart®

HOW TO ORDER

$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $9.45 Total: $945.00
150 $10.92 Total: $546.00
125 $12.81 Total: $320.25
110 $15.12 Total: $151.20
15 $17.85 Total: $89.25

Data sheet

Molecular FormulaC22H21ClF3N3O3
Molecular Weight467.87
CAS Numbers878983-38-1
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymAKOS-22; AKOS 22; AKOS22; AKOS-022075291; AKOS 022075291; AKOS022075291
IUPAC/Chemical Name1-(4-Chloro-phenyl)-3-[4-(4-trifluoromethoxy-phenylamino)-piperidin-1-yl]-pyrrolidine-2,5-dione
InChl KeyZZVCWIMICOFQNJ-UHFFFAOYSA-N
InChl CodeInChI=1S/C22H21ClF3N3O3/c23-14-1-5-17(6-2-14)29-20(30)13-19(21(29)31)28-11-9-16(10-12-28)27-15-3-7-18(8-4-15)32-22(24,25)26/h1-8,16,19,27H,9-13H2
SMILES CodeO=C(C(N1CCC(NC2=CC=C(OC(F)(F)F)C=C2)CC1)C3)N(C4=CC=C(Cl)C=C4)C3=O
ReferencesDanya Ben-Hail 1 , Racheli Begas-Shvartz 1 , Moran Shalev 1 , Anna Shteinfer-Kuzmine 1 , Arie Gruzman 2 , Simona Reina 3 ,4 , Vito De Pinto 3 and Varda Shoshan-Barmatz 1, * Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondria dysfunction. JBC Papers in Press. Published on October 13, 2016 as Manuscript M116.744284.

More info

Inhibitor of both VDAC1 oligomerization and apoptosis in a concentration-dependent manner, with 50% inhibition of both apoptosis and VDAC1 oligomerization

Customers who bought this product also bought: