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EMBL
AOB36485
CAS: 445222-91-3
Chemical Name: CID-704946; 2-Amino-1'-methyl-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile
363 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $33.15 | Total: $165.75 |
| 1 | 10 | $28.08 | Total: $280.80 |
| 1 | 25 | $23.79 | Total: $594.75 |
| 1 | 50 | $20.28 | Total: $1,014.00 |
| 1 | 100 | $17.55 | Total: $1,755.00 |
Overview
Novel inhibitor of MuRF1, attenuating skeletal muscle atrophy and dysfunction in cardiac cachexia
Chemical Properties
| Molecular Formula | C18H15N3O3 |
| Molecular Weight | 321.34 |
| CAS Numbers | 445222-91-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (4R)-2-Amino-1'-methyl-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile |
| InChl Key | VXTHFLXWLSPJSP-GOSISDBHSA-N |
| InChl Code | InChI=1S/C18H15N3O3/c1-21-12-6-3-2-5-10(12)18(17(21)23)11(9-19)16(20)24-14-8-4-7-13(22)15(14)18/h2-3,5-6H,4,7-8,20H2,1H3/t18-/m1/s1 |
| SMILES Code | N#CC1=C(N)OC2=C(C(CCC2)=O)[C@]13C(N(C)C4=C3C=CC=C4)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
CID-704946; MuRF1-IN-1
References
1) Bowen TS, Adams V, Werner S, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.
