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Sotorasib (AMG-510)
AOB16401
CAS: 2296729-00-3
Chemical Name: AMG-510; 6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $7.65 | Total: $765.00 |
| 1 | 50 | $8.84 | Total: $442.00 |
| 1 | 25 | $10.37 | Total: $259.25 |
| 1 | 10 | $12.24 | Total: $122.40 |
| 1 | 5 | $14.45 | Total: $72.25 |
Data sheet
| Molecular Formula | C30H30F2N6O3 |
| Molecular Weight | 560.61 |
| CAS Numbers | 2252403-56-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | AMG-510; AMG 510; AMG510; Sotorasib, |
| IUPAC/Chemical Name | 4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one |
| InChl Key | NXQKSXLFSAEQCZ-SFHVURJKSA-N |
| InChl Code | InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1 |
| SMILES Code | O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1 |
| References | 1) Ryan MB, Fece de la Cruz F, Phat S, Myers DT, Wong E, Shahzade HA, Hong CB, Corcoran RB. Vertical pathway inhibition overcomes adaptive feedback resistance to KRASG12C inhibition. Clin Cancer Res. 2019 Nov 27. pii: clincanres.3523.2019. doi: 10.1158/1078-0432.CCR-19-3523. [Epub ahead of print] PubMed PMID: 31776128. 2) AMG 510 First to Inhibit "Undruggable" KRAS. Cancer Discov. 2019 Aug;9(8):988-989. doi: 10.1158/2159-8290.CD-NB2019-073. Epub 2019 Jun 12. PubMed PMID: 31189530. |
More info
First-in-class targeted covalent inhibitor of KRASG12C for the treatment of locally advanced or metastatic non-small cell lung cancer with the KRASG12C mutation
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