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BMS-1001 hydrochloride
AOB31743
CAS No: 2113650-04-5
Chemical Name: (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine hydrochloride
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $16.88 | Total: $1,687.50 |
| 1 | 50 | $19.50 | Total: $975.00 |
| 1 | 25 | $22.88 | Total: $571.88 |
| 1 | 10 | $27.00 | Total: $270.00 |
| 1 | 5 | $31.88 | Total: $159.38 |
Data sheet
| Molecular Formula | C35H35ClN2O7 |
| Molecular Weight | 631.12 |
| CAS Numbers | 2113650-04-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | BMS-1001 HCl; BMS 1001 HCl; BMS1001 HCl; BMS-1001 hydrochloride; BMS 1001 hydrochloride; BMS1001 hydrochloride |
| IUPAC/Chemical Name | (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine hydrochloride |
| InChl Key | VKDUZONDVBDCAX-VNUFCWELSA-N |
| InChl Code | InChI=1S/C35H34N2O7.ClH/c1-22-13-28(18-37-30(19-38)35(39)40)33(43-20-25-6-3-5-24(14-25)17-36)16-32(22)44-21-27-7-4-8-29(23(27)2)26-9-10-31-34(15-26)42-12-11-41-31;/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40);1H/t30-;/m1./s1 |
| SMILES Code | OC[C@H](C(O)=O)NCC1=CC(C)=C(OCC2=CC=CC(C3=CC=C4OCCOC4=C3)= C2C)C=C1OCC5=CC=CC(C#N)=C5.[H]Cl |
| References | Skalniak L, Zak KM, Guzik K, Magiera K, Musielak B, Pachota M, Szelazek B, Kocik J, Grudnik P, Tomala M, Krzanik S, Pyrc K, Dömling A, Dubin G, Holak TA. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181 |
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Novel potent PD-1/PD-L1 interaction inhibitor
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