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Belvarafenib (GDC-5573)
AOB13570
CAS: 1446113-23-0
Chemical Name: GDC-5573; HM95573; 4-Amino-N-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $17.55 | Total: $1,755.00 |
| 1 | 50 | $20.28 | Total: $1,014.00 |
| 1 | 25 | $23.79 | Total: $594.75 |
| 1 | 10 | $28.08 | Total: $280.80 |
| 1 | 5 | $33.15 | Total: $165.75 |
Data sheet
| Molecular Formula | C23H18ClFN6OS |
| Molecular Weight | 480.94 |
| CAS Numbers | 1446113-23-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | GDC-5573; GDC5573; GDC 5573; HM95573; HM 95573; HM-95573; RG6185; RG-6185; RG 6185 |
| IUPAC/Chemical Name | 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-7-methyl-4a,8a-dihydroisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide |
| InChl Key | PNKLALSHRLTGTH-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H18ClFN6OS/c1-11-7-13-12(5-6-27-22(13)30-16-4-2-3-15(24)18(16)25)17(8-11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10,12-13H,1H3,(H,27,30)(H,31,32)(H2,26,28,29) |
| SMILES Code | FC1=C(Cl)C=CC=C1NC2=NC=CC3C(NC(C4=CSC5=C4N=CN=C5N)=O)=CC(C)=CC23 |
| References | InHwan Bae, et al. Antitumor activity of the selective RAF inhibitor HM95573 in melanoma. AACR 2015 |
More info
Novel and selective RAF kinase inhibitor, binding to and inhibiting the B-Raf mutant V600E and C-Raf
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