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AOB6215
CAS No: 955272-06-7
Chemical Name: 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione
AOBIOUS launched this product in 2015
CITATIONS - Publications That Use AOBIOUS Product
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Availability date:
Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $6.75 | Total: $675.00 |
1 | 50 | $7.80 | Total: $390.00 |
1 | 25 | $9.15 | Total: $228.75 |
1 | 10 | $10.80 | Total: $108.00 |
1 | 5 | $12.75 | Total: $63.75 |
Molecular Formula | C19H15ClN4O2 |
Molecular Weight | 366.80 |
CAS Numbers | 955272-06-7 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO |
Purity | 98% by HPLC |
Synonym | GKT136901; GKT-136901; GKT 136901 |
IUPAC/Chemical Name | 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione |
InChl Key | DNKYHHFCPXKFIY-UHFFFAOYSA-N |
InChl Code | InChI=1S/C19H15ClN4O2/c1-12-18-15(10-17(25)23(12)11-13-6-4-5-9-21-13)22-24(19(18)26)16-8-3-2-7-14(16)20/h2-10,22H,11H2,1H3 |
SMILES Code | O=C1N(C2=CC=CC=C2Cl)NC(C1=C(C)N3CC4=NC=CC=C4)=CC3=O |
References | 1) Vendrov AE, Madamanchi NR, Niu XL, Molnar KC, Runge M, Szyndralewiez C, Page P, Runge MS. NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis. J Biol Chem. 2010 Aug 20;285(34):26545-57 2) Appukuttan B, Ma Y, Stempel A, Ashander LM, Deliyanti D, Wilkinson-Berka JL, Smith JR. Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells. Clin Exp Ophthalmol. 2018 Jan 23. 3) Geis C, Geuss E, Sommer C, Schmidt HH, Kleinschnitz C. NOX4 is an early initiator of neuropathic pain. Exp Neurol. 2017 Feb;288:94-103. doi: 10.1016/j.expneurol.2016.11.008. Epub 2016 Nov 14 |
Novel NOX1/4 inhibitor, blocking tumor angiogenesis through a PPARα mediated mechanism and selective scavenging of peroxynitrite (PON)