JWG-071

JWG-071

AOB36251

CAS: 2250323-50-1

Chemical Name: 11-(sec-Butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

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1998 Items

$17.00

$17.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $14.45 Total: $72.25
110 $12.24 Total: $122.40
125 $10.37 Total: $259.25
150 $8.84 Total: $442.00
1100 $7.65 Total: $765.00

Overview

The first reported kinase-selective chemical probe for ERK5

Chemical Properties

Molecular FormulaC34H44N8O3
Molecular Weight612.78
CAS Numbers2250323-50-1
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name11-(sec-Butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one
InChl KeyACWOMSOYIIVIRV-UHFFFAOYSA-N
InChl CodeInChI=1S/C34H44N8O3/c1-6-23(2)42-28-10-8-7-9-26(28)33(44)39(4)29-22-35-34(37-31(29)42)36-27-12-11-24(21-30(27)45-5)32(43)41-15-13-25(14-16-41)40-19-17-38(3)18-20-40/h7-12,21-23,25H,6,13-20H2,1-5H3,(H,35,36,37)
SMILES CodeO=C1C2=CC=CC=C2N(C(C)CC)C3=NC(NC4=CC=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4OC)=NC=C3N1C

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

JWG071; JWG 071; JWG-071

References

Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. PubMed PMID: 30102854; PubMed Central PMCID: PMC6333101.

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