Kinase Inhibitors

AMG-511 View larger

AMG-511

AOB33711

CAS No:1253573-53-3

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$27.00

$27.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $12.15 Total: $1,215.00
150 $14.04 Total: $702.00
125 $16.47 Total: $411.75
110 $19.44 Total: $194.40
15 $22.95 Total: $114.75

Data sheet

Molecular FormulaC22H28FN9O3S
Molecular Weight517.6
CAS Numbers1253573-53-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO or Ethanol
Stock Solution Guide10 mMol/5.18 mg/1 mL Solvent
Purity99% (HPLC)
SynonymAMG-511; AMG 511; AMG511.
IUPAC/Chemical Name(R)-4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
InChl KeyKUGIFHQBIIHRIZ-CYBMUJFWSA-N
InChl CodeInChI=1S/C22H28FN9O3S/c1-13(31-5-7-32(8-6-31)36(4,33)34)15-9-17(20-27-14(2)28-22(24)30-20)19(25-11-15)29-16-10-18(23)21(35-3)26-12-16/h9-13H,5-8H2,1-4H3,(H,25,29)(H2,24,27,28,30)/t13-/m1/s1
SMILES CodeNC1=NC(C2=CC([C@H](N3CCN(S(=O)(C)=O)CC3)C)=CN=C2NC4=CC(F)=C(OC)N=C4)=NC(C)=N1
References1) Lanman BA, et al., Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5630-4.

2) Subramanian R, et al., P450-mediated O-demethylated metabolite is responsible for rat hepatobiliary toxicity of pyridyltriazine-containing PI3K inhibitors. Toxicol Sci. 2014 Nov;142(1):298-310.

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An orally bioavailable, highly potent and selective pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor

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