Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.95 | Total: $114.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 100 | $12.15 | Total: $1,215.00 |
Overview
An orally bioavailable, highly potent and selective pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor
Chemical Properties
| Molecular Formula | C22H28FN9O3S |
| Molecular Weight | 517.6 |
| CAS Numbers | 1253573-53-3 |
| Solubility | DMSO or Ethanol |
| Stock Solution Guide | 10 mMol/5.18 mg/1 mL Solvent |
| Purity | 99% (HPLC) |
| IUPAC/Chemical Name | (R)-4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine |
| InChl Key | KUGIFHQBIIHRIZ-CYBMUJFWSA-N |
| InChl Code | InChI=1S/C22H28FN9O3S/c1-13(31-5-7-32(8-6-31)36(4,33)34)15-9-17(20-27-14(2)28-22(24)30-20)19(25-11-15)29-16-10-18(23)21(35-3)26-12-16/h9-13H,5-8H2,1-4H3,(H,25,29)(H2,24,27,28,30)/t13-/m1/s1 |
| SMILES Code | NC1=NC(C2=CC([C@H](N3CCN(S(=O)(C)=O)CC3)C)=CN=C2NC4=CC(F)=C(OC)N=C4)=NC(C)=N1 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
AMG-511; AMG 511; AMG511.
References
1) Lanman BA, et al., Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5630-4.
2) Subramanian R, et al., P450-mediated O-demethylated metabolite is responsible for rat hepatobiliary toxicity of pyridyltriazine-containing PI3K inhibitors. Toxicol Sci. 2014 Nov;142(1):298-310.
