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FKGK18
AOB4846
CAS No: 1071001-09-6
Chemical Name: 1,1,1-Trifluoro-6-(2-naphthalenyl)-2-hexanone
779 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $18.70 | Total: $93.50 |
| 1 | 10 | $15.84 | Total: $158.40 |
| 1 | 25 | $13.42 | Total: $335.50 |
| 1 | 50 | $11.44 | Total: $572.00 |
| 1 | 100 | $9.90 | Total: $990.00 |
Overview
Novel Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A2 (iPLA2β) for Preventing Beta-Cell Apoptosis and Diabetes
Chemical Properties
| Molecular Formula | C16H15F3O |
| Molecular Weight | 280.28 |
| CAS Numbers | 1071001-09-6 |
| IUPAC/Chemical Name | 1,1,1-trifluoro-6-(2-naphthalenyl)-2-hexanone |
| InChl Key | VCWWTQMRNJSJGC-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C16H15F3O/c17-16(18,19)15(20)8-4-1-5-12-9-10-13-6-2-3-7-14(13)11-12/h2-3,6-7,9-11H,1,4-5,8H2 |
| SMILES Code | O=C(C(F)(F)F)CCCCC1=CC2=CC=CC=C2C=C1 |
Synonyms
FKGK18; FKGK-18; FKGK 18
References
1) Kokotos, G., et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J. Med. Chem. 53(9), 3602-3610 (2010).
2) Ali, T., et al. Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): Candidate drug for preventing β-cell apoptosis and diabetes. PLoS One 8(8):e71748, (2013).
3) Bone, R.N., et al. Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes 64(2), 541-554 (2015).
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