Kinase Inhibitors

 AMPK Activator 991 View larger

EX229 (AMPK Activator 991)

AOB8150

CAS No: 1219739-36-2

 

Chemical Name: Compound 991; 1-(2,6-Dichlorophenyl)-6-[[4-(2-hydroxyethoxy)phenyl]methyl]-3-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-4-one

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$17.00

$17.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $7.65 Total: $765.00
50 $8.84 Total: $442.00
25 $10.37 Total: $259.25
10 $12.24 Total: $122.40
5 $14.45 Total: $72.25

Data sheet

Molecular FormulaC24H18ClN3O3
Molecular Weight431.87
CAS Numbers 1219739-36-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymEX-229; EX 229; EX229; AMPK Activator 991
IUPAC/Chemical Name5-{[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy}-2-methyl-benzoic acid
InChl KeyFHWSAZXFPUMKFL-UHFFFAOYSA-N
InChl CodeInChI=1S/C24H18ClN3O3/c1-13-3-5-16(10-17(13)23(29)30)31-24-26-20-11-18(19(25)12-21(20)27-24)14-4-6-22-15(9-14)7-8-28(22)2/h3-12H,1-2H3,(H,26,27)(H,29,30)
SMILES CodeO=C(O)C1=CC(OC2=NC3=CC(C4=CC5=C(N(C)C=C5)C=C4)=C(Cl)C=C3N2)=CC=C1C
References1) Xu YY, Chen FL, Ji F, Fei HD, Xie Y, Wang SG. Activation of AMP-activated protein kinase by compound 991 protects osteoblasts from dexamethasone. Biochem Biophys Res Commun. 2017 Nov 21. pii: S0006-291X(17)32311-2.

2) Song Y, Wang Z, Zhang B, Zhang Y, Zhang W, Yang C, Meng F, Feng X. Determination of a novel anticancer AMPK activator hernandezine in rat plasma and tissues with a validated UHPLC-MS/MS method: Application to pharmacokinetics and tissue distribution study. J Pharm Biomed Anal. 2017 Jul 15;141:132-139.

3) Willows R, Navaratnam N, Lima A, Read J, Carling D. Effect of different γ-subunit isoforms on the regulation of AMPK. Biochem J. 2017 May 9;474(10):1741-1754.

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Novel AMPK activator, increasing AMPK activity of both AMPKgamma1- and AMPKgamma3-containing complexes in mouse skeletal muscle

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