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MK-8722
AOB33226
CAS: 1394371-71-1
Chemical Name: (3R,3aR,6R,6aR)-6-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol
AOBIOUS launched this product in 2018
CITATIONS - Publications That Use AOBIOUS Product
1) Bioeng Transl Med. 2021 Jan; 6(1): e10187.
2) Biochem J (2022) 479 (11): 1181–1204.
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $7.65 | Total: $765.00 |
| 1 | 50 | $8.84 | Total: $442.00 |
| 1 | 25 | $10.37 | Total: $259.25 |
| 1 | 10 | $12.24 | Total: $122.40 |
| 1 | 5 | $14.45 | Total: $72.25 |
Data sheet
| Molecular Formula | C24H20ClN3O4 |
| Molecular Weight | 449.89 |
| CAS Numbers | 1394371-71-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | MK-8722; MK 8722; MK8722 |
| IUPAC/Chemical Name | (3R,3aR,6R,6aR)-6-((6-([1,1'-biphenyl]-4-yl)-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol |
| InChl Key | VEGCGBKTFKSLJB-MCEIDBOGSA-N |
| InChl Code | InChI=1S/C24H20ClN3O4/c25-19-16(15-8-6-14(7-9-15)13-4-2-1-3-5-13)10-26-23-20(19)27-24(28-23)32-18-12-31-21-17(29)11-30-22(18)21/h1-10,17-18,21-22,29H,11-12H2,(H,26,27,28)/t17-,18-,21-,22-/m1/s1 |
| SMILES Code | ClC1=C2C(NC(O[C@@H]3CO[C@@]4([H])[C@]3([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C(C6=CC=CC=C6)C=C5 |
| References | 1) Weihrauch M, etc. Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochem Pharmacol. 2017 Oct 20. pii: S0006-2952(17)30636-6. 2) Myers RW, etc. Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy. Science. 2017 Aug 4;357(6350):507-511. 3) Danqing Feng, etc. Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase Publication Date (Web): December 1, 2017 (Letter) |
More info
Novel Systemic pan-AMPK activator, improving glucose homeostasis but inducing cardiac hypertrophy
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