Pathway Inhibitors

BRD-K98645985 View larger

BRD-K98645985

AOB36606

CAS: 1357647-78-9

 

Chemical Name: 1-Isopropyl-3-((3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-(4-(pyridin-2-yl)benzyl)-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1]oxa[4,9]diazacyclododecin-12-yl)urea

AOBIOUS launched this product in 2020

CITATIONS - Publications That Use AOBIOUS Product

1) Nature. 2022 Jul; 607(7917): 135–141

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$339.00

$339.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $152.55 Total: $15,255.00
150 $176.28 Total: $8,814.00
125 $206.79 Total: $5,169.75
110 $244.08 Total: $2,440.80
15 $288.15 Total: $1,440.75

Data sheet

Molecular FormulaC33H43N5O4
Molecular Weight573.74
CAS Numbers1357647-78-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymBRDK98645985, BRD K98645985; BD98; BD-98; BD 98
IUPAC/Chemical Name1-Isopropyl-3-((3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-(4-(pyridin-2-yl)benzyl)-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1]oxa[4,9]diazacyclododecin-12-yl)urea
SMILES CodeO=C(NC1=CC=C(OC[C@H](C)N(CC2=CC=C(C3=NC=CC=C3)C=C2)C[C@H](C)[C@@H](OC)CN(C)C4=O)C4=C1)NC(C)C
References1) Marian CA, et al. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.

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Novel inhibitor of BAF transcriptional repression, targeting specific ARID1A-containing BAF complexes, reverseing HIV-1 latency and being non-toxic to T cells

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