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HTH-02-006
AOB36960
CAS: N/A
Chemical Name: N-(3-((5-Iodo-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $58.05 | Total: $5,805.00 |
| 1 | 50 | $67.08 | Total: $3,354.00 |
| 1 | 25 | $78.69 | Total: $1,967.25 |
| 1 | 10 | $92.88 | Total: $928.80 |
| 1 | 5 | $109.65 | Total: $548.25 |
Data sheet
| Molecular Formula | C25H29IN6O3 |
| Molecular Weight | 588.45 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | HTH-02-006; HTH02006; HTH 02 006; HTH-02006; HTH 02006; HTH02006; |
| IUPAC/Chemical Name | N-(3-((5-iodo-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin4-yl)oxy)phenyl)propionamide |
| InChl Key | KQMWYEJQANQTDM-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C25H29IN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30) |
| SMILES Code | IC1=CN=C(NC2=C(OC)C=C(N3CCN(C)CC3)C=C2)N=C1OC4=CC=CC(NC(CC)=O)=C4 |
| References | 1) Dey A, Varelas X, Guan KL. (2020) Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov, 19 (7): 480-494. [PMID:32555376] 2) Juan WC, Hong W. (2016) Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy. Genes (Basel), 7 (9). [PMID:27589805] 3) Yuan WC, Pepe-Mooney B, Galli GG, Dill MT, Huang HT, Hao M, Wang Y, Liang H, Calogero RA, Camargo FD. (2018) NUAK2 is a critical YAP target in liver cancer. Nat Commun, 9 (1): 4834. [PMID:30446657] |
More info
Novel semispecific NUAK2 inhibitor, reducing levels of phosphorylated MYPT1 in HuCCT-1 cells indicating its activity on NUAK2 and/or NUAK1, which can also phosphorylate MYPT1
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