Protein Control Ligand

Protein Control Ligand
Pathway Inhibitors
- Enzyme Inhibitors
- Protein Inhibitors
- Transporter Inhibitors
  - ATPases
- Cell Inhibition
- Synthase
- Receptor Tyrosine Phosphatases (RTP)
- AChE
- Peptidase
- Autophagy
- Toll-Like Receptor (TLR)
Function Modulators
- Potentiators
- Allosteric
- Votage-Gated Ion Channel Blockers
- Major Facilitator Superfamily (MFS) Transporters
- Ligand-Gated Ion Channels
- Aquaporins
- Chlorine Channels
- Connexins and Pannexins
- KCC2 - K-Cl co-transporter
- ADC cytotoxin
- ADC Linker
- CFTR
- CCK
- Monoamine Transporter
- Proton pump
Activators
- Receptor Activators
- Inducer
- Openers
- Potassium Channel
G Protein-Coupled Receptor Ligands
- 5HT Receptors
- Adrenoceptor
- Angiotensin Receptor
- Cannabinoid Receptors
- CCK Receptors
- DA Receptors
- EAA Receptors
- Ghrelin Receptors
- GABA Receptors
- Histamine Receptors
- Leukotriene Receptors
- Metabotropic Glutamate Receptors
- Motilin Receptors
- Muscarinic Receptor
- Neuropeptide Receptors
- Opioid Receptors
- Orexin Receptors
- Orphan Receptors
- Prostanoid Receptors
- Proteinase-Activated Receptors
- Purinergic Receptors
- Ryanodine receptor
- Sigma Receptors
- Thrombin Receptor
- Vaniloid Receptor
- VIP and PACAP Receptors
- Neurotensin Receptors
- Urotensin Receptor
- Imidazoline receptor
- SMO Receptors
- Apelin Receptor
- β-arrestin/β2-adaptin
- KDM4
- Glucocorticoid Receptor
- Laminin Receptor
- AHR
- Amylin Receptor
- Bombesin Receptor
- Bradykinin Receptor
- CFTR
- CGRP Receptor
- CRFR
- Endothelin Receptor
- Ephrin Receptor
- Farnesoid X receptor (FXR)
- Glucagon Receptor
Nuclear Receptor Ligands
- Retinoic Acid, X and Orphans Receptors
- Rev-Erb Receptors
- Hepatocyte Nuclear Factors Receptors
- COUP-TF Like Receptors
- Growth Factors Receptors
- Steroid Hormone Receptors
- DAX-Like Receptors
- Vitamin Related Receptors
- PPARs
- DNA Polymerase
- CRFR
- NOD
- RAAS
GDNF Receptors
TNF Receptors
Transcription Factors
Chemokines
- CXCR-2
- CXCR-3
- CXCR-4
- CXCR-7
Cytokine Receptors
- IL Receptors
- Interferon Receptors
- Integrins
- Toll-Like Receptors
- NOD-Like Receptors
Biomarkers and Buffer Solutions
- Universal DNA Markers
- Biological Buffers
- Biomarker
Molecular Probes
- Fluorescence Probes
- Chelating Agents
- Luminescent Probes
- Optical Probes
Stem Cell Research
- Reporter of Gene Expression
- CiPSC Cocktail
  - TSPC - CiPSC Cocktail
  - VC6TF - CiPSC Cocktail
- Complement System
Alzheimer's Disease
Apoptosis
Cancer Research
Epigenetics
Metabolites
PET/SPECT Imaging Precursors
Customized Screening Library
- Target Diversified Drug Like Small Molecule Library
- Target Focused Small Drug Like Molecule Library
Ultra Pure Pharmacological Standard
Tissue Microarray (TMA)
- Bladder
- Brain
- Breast
- Cervix
- Colon
- Digestive Sytem
- Esophagus
- Glucose Test Strips
- Kidney
- Large Intestine
- Liver
- Lung
- Lymphoma
- Multiple Organ
- Multiple Organ IFetus)
- Pancreas
- Prostate
- Rectum
- Reproductive System
- Stomach
- Thyroid
- Urological Sytem
Proteins and Antibodies
- Proteins and Enzymes
  - Cytokines and Chemokines
- Antibodies and Kits
  - RABBIT POLYCLONAL
  - RABBIT MONOCLONAL
- Protein Digestion Sufactant
- Cell Culture
Primary Cells
ELISA KIT
Natural Products
Lab Equipments
Humanized Mice for PDX Platform
Rare Chemicals
Custom Synthesis
Antibacterial
Antifungal
Antioxidant
Antiviral
Molecular Glues
PROTAC Linker
SARS-CoV

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Shield-1

Cat No: AOB1848

Condition

CAS No: 914805-33-7

(for solution check AOB1848S)

AOBIOUS launched this product in 2014

CITATIONS - Publications That Use AOBIOUS Product

1) Molecular Cell 70:801 (2018)

2) Gene Expression Omnibus (2018)

3) Nucleic Acid Research 46:10132 (2018)

4) Vaccines 7:104 (2019)

5) Cell Rep. 2018 Dec 4; 25(10): 2891–2903.e5.

6)EMBO Rep. 2020 Nov 5; 21(11): e50636

More details

481 Item Items

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$41.65	Total: $208.25
1	10	$35.28	Total: $352.80
1	25	$29.89	Total: $747.25
1	50	$25.48	Total: $1,274.00
1	100	$22.05	Total: $2,205.00

Data sheet

Molecular Formula	C42H56N2O10
Molecular Weight	748.90
CAS Numbers	914805-33-7
Storage Condition	0°C (short term), -20°C (long term), desiccated
Solubility	DMSO and Alcohol
Purity	98% by HPLC
IUPAC/Chemical Name	(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate
InChl Key	NMFHJNAPXOMSRX-PUPDPRJKSA-N
InChl Code	InChI=1S/C42H56N2O10/c1-7-33(31-27-38(49-4)40(51-6)39(28-31)50-5)41(45)44-18-9-8-13-34(44)42(46)54-35(16-14-29-15-17-36(47-2)37(25-29)48-3)30-11-10-12-32(26-30)53-24-21-43-19-22-52-23-20-43/h10-12,15,17,25-28,33-35H,7-9,13-14,16,18-24H2,1-6H3/t33-,34-,35+/m0/s1
SMILES Code	O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5
References	1) Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11. 2) Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17(1):763-770.

More info

Novel cell permeable small molecule redulator of specific protein functions

The Shield-1 ligand can simultaneously stabilizes and destabilizes a protein of interest depending on the amount of the ligand used within the targeted cell.

Reference (click for link):

1) BioTechniques

The water soluble form of the Shield-1 ligand is also avaialble at AOBIOUS as AOB6677 (Aqua-Shield-1).