Protein Control Ligand

Shield-1 View larger

Shield-1

AOB1848

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HOW TO ORDER

$79.00

$79.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $35.55 Total: $3,555.00
50 $41.08 Total: $2,054.00
25 $48.19 Total: $1,204.75
10 $56.88 Total: $568.80
5 $67.15 Total: $335.75

Data sheet

Molecular FormulaC42H56N2O10
Molecular Weight748.90
CAS Numbers914805-33-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Alcohol
Purity98% by HPLC
IUPAC/Chemical Name (1R)-3-(3,4-Dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate
InChl KeyNMFHJNAPXOMSRX-PUPDPRJKSA-N
InChl CodeInChI=1S/C42H56N2O10/c1-7-33(31-27-38(49-4)40(51-6)39(28-31)50-5)41(45)44-18-9-8-13-34(44)42(46)54-35(16-14-29-15-17-36(47-2)37(25-29)48-3)30-11-10-12-32(26-30)53-24-21-43-19-22-52-23-20-43/h10-12,15,17,25-28,33-35H,7-9,13-14,16,18-24H2,1-6H3/t33-,34-,35+/m0/s1
SMILES CodeO=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5
References1) Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11.

2) Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17(1):763-770.

More info

Novel cell permeable small molecule redulator of specific protein functions

The Shield-1 ligand can simultaneously stabilizes and destabilizes a protein of interest depending on the amount of the ligand used within the targeted cell.

Reference (click for link):

1) BioTechniques 

The water soluble form of the Shield-1 ligand is also avaialble at AOBIOUS as AOB6677 (Aqua-Shield-1).

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