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RG7834 View larger

RG7834

AOB33774

CAS: 2072057-17-9

 

Chemical Name: RG-7834; RO-7020322; (6S)-6-Isopropyl-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid

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$15.00

$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $6.75 Total: $675.00
150 $7.80 Total: $390.00
125 $9.15 Total: $228.75
110 $10.80 Total: $108.00
15 $12.75 Total: $63.75

Data sheet

Molecular FormulaC22H27NO6
Molecular Weight401.18
CAS Numbers2072057-17-9 (S-isomer)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymRG7834; RG 7834; RG-7834; RO7020322; RO 7020322; RO-7020322
IUPAC/Chemical Name(6S)-6-Isopropyl-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid
InChl KeyKBXLMOYQNDMHQT-KRWDZBQOSA-N
InChl Code InChI=1S/C22H27NO6/c1-13(2)17-8-14-9-21(29-7-5-6-27-3)20(28-4)10-15(14)18-11-19(24)16(22(25)26)12-23(17)18/h9-13,17H,5-8H2,1-4H3,(H,25,26)/t17-/m0/s1
SMILES CodeO=C(C1=CN2[C@H](C(C)C)CC3=CC(OCCCOC)=C(OC)C=C3C2=CC1=O)O
References1) Mueller H, etc PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization. Hepatology. 2019 Apr;69(4):1398-1411.

2) Han X, etc. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Dec 13;61(23):10619-10634.

3) Mueller H, etc. A novel orally available small molecule that inhibits hepatitis B virus expression. J Hepatol. 2018 Mar;68(3):412-420.

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Novel, potent and orally bioavailable inhibitor of HBV gene expression

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