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> Pathway Inhibitors>Enzyme Inhibitors>Ubiquitin-Activating Enzyme>(R)-FT671

Ubiquitin-Activating Enzyme

(R)-FT671 View larger

(R)-FT671

AOB12773

CAS No: 1959551-27-9 (R-isomer) but if you look more active S-isomer (1959551-26-8) click: (S-isomer :Active Isomer)

 

AOBIOUS launched this product in 2020

CITATIONS - Publications That Use AOBIOUS Product

1) Journal of Virology, 16 Jan 2025, 99(2)

More details

3986 Items

Alternative choice for FT671 is its analog AOB36638

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HOW TO ORDER

$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC24H23F4N7O3
Molecular Weight533.49
CAS Numbers1959551-27-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
Synonym(R)FT671; R-FT671; (R)FT 671; R-FT 671
IUPAC/Chemical Name (R)-5-((1-(4,4-Difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
SMILES CodeO=C1C2=C(N(C3=CC=C(F)C=C3)N=C2)N=CN1CC4(O)CCN(C(C[C@@H](N5N=C(F)C=C5)C(F)F)=O)CC4
References1) Turnbull AP, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017 Oct 26;550(7677):481-486.

More info

R-isomer of FT671. FT671 (S-isomer) is a novel potent and selective inhibitor of ubiquitin-specific protease 7 (USP7), destabilizing USP7 substrates including MDM2, increasing levels of p53, and resulting in the transcription of p53 target genes, inducing the tumour suppressor p21, and inhibiting tumour growth.

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