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Ubiquitin-Activating Enzyme
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(R)-FT671
AOB12773
CAS No: 1959551-27-9 (R-isomer) but if you look more active S-isomer (1959551-26-8) click: (S-isomer :Active Isomer)
Chemical Name: (R)-5-((1-(4,4-Difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Alternative choice for FT671 is its analog AOB36638
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $9.45 | Total: $945.00 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 5 | $17.85 | Total: $89.25 |
Data sheet
| Molecular Formula | C24H23F4N7O3 |
| Molecular Weight | 533.49 |
| CAS Numbers | 1959551-27-9 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | (R)FT671; R-FT671; (R)FT 671; R-FT 671 |
| IUPAC/Chemical Name | (R)-5-((1-(4,4-Difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| SMILES Code | O=C1C2=C(N(C3=CC=C(F)C=C3)N=C2)N=CN1CC4(O)CCN(C(C[C@@H](N5N=C(F)C=C5)C(F)F)=O)CC4 |
| References | 1) Turnbull AP, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017 Oct 26;550(7677):481-486. |
More info
R-isomer of FT671. FT671 (S-isomer) is a novel potent and selective inhibitor of ubiquitin-specific protease 7 (USP7), destabilizing USP7 substrates including MDM2, increasing levels of p53, and resulting in the transcription of p53 target genes, inducing the tumour suppressor p21, and inhibiting tumour growth.