Lemborexant

Lemborexant

AOB87671

CAS: 1369764-02-2

 

Chemical Name: E-2006; (1R,2S)-2-[(2,4-Dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide

More details

942 Items

$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Overview

Novel dual antagonist of the orexin OX1 and OX2 receptors

Chemical Properties

Molecular FormulaC22H20F2N4O2
Molecular Weight410.43
CAS Numbers1369764-02-2
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide
InChl KeyMUGXRYIUWFITCP-PGRDOPGGSA-N
InChl CodeInChI=1S/C22H20F2N4O2/c1-13-19(11-25-14(2)27-13)30-12-22(15-4-3-5-16(23)8-15)9-18(22)21(29)28-20-7-6-17(24)10-26-20/h3-8,10-11,18H,9,12H2,1-2H3,(H,26,28,29)/t18-,22+/m0/s1
SMILES CodeO=C([C@H]1[C@@](C2=CC=CC(F)=C2)(COC3=CN=C(C)N=C3C)C1)NC4=NC=C(F)C=C4

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

E-2006; E 2006; E2006; Lemborexant; Dayvigo.

References

1) Rosenberg R, Murphy P, Zammit G, Mayleben D, Kumar D, Dhadda S, Filippov G, LoPresti A, Moline M. Comparison of Lemborexant With Placebo and Zolpidem Tartrate Extended Release for the Treatment of Older Adults With Insomnia Disorder: A Phase 3 Randomized Clinical Trial. JAMA Netw Open. 2019 Dec 2;2(12):e1918254. doi: 10.1001/jamanetworkopen.2019.18254. PubMed PMID: 31880796.

2) Mahoney CE, Mochizuki T, Scammell TE. Dual orexin receptor antagonists increase sleep and cataplexy in wild type mice. Sleep. 2019 Dec 13. pii: zsz302. doi: 10.1093/sleep/zsz302. [Epub ahead of print] PubMed PMID: 31830270.

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