EPZ-025654

EPZ-025654

AOB33871

CAS No: 1888328-89-9

 

Chemical Name: GSK35336023; (R)-1-(3-(4-(2-(Azetidin-1-yl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-2-yl)-4-chlorophenoxy)-3-(methylamino)propan-2-ol

More details

314 Items

$37.50

$37.50 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $31.88 Total: $159.38
110 $27.00 Total: $270.00
125 $22.88 Total: $571.88
150 $19.50 Total: $975.00
1100 $16.88 Total: $1,687.50

Overview

Novel potent, selective arginine methyltransferase CARM1 inhibitor

Chemical Properties

Molecular FormulaC29H33ClN8O3
Molecular Weight577.09
CAS Numbers1888328-89-9
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name(R)-1-(3-(4-(2-(Azetidin-1-yl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-2-yl)-4-chlorophenoxy)-3-(methylamino)propan-2-ol hydrochloride
InChl KeyFJRSBGGFLPVXPH-HXUWFJFHSA-N
InChl CodeInChI=1S/C29H33ClN8O3/c1-16-26(25-17(2)36-41-18(25)3)34-27(22-10-21(6-7-23(22)30)40-15-20(39)12-31-4)35-28(16)38-13-19-11-32-29(33-24(19)14-38)37-8-5-9-37/h6-7,10-11,20,31,39H,5,8-9,12-15H2,1-4H3/t20-/m1/s1
SMILES CodeO[C@H](CNC)COC1=CC=C(Cl)C(C2=NC(C3=C(C)ON=C3C)=C(C)C(N4CC5=NC(N6CCC6)=NC=C5C4)=N2)=C1

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

EPZ-025654; EPZ 025654; EPZ025654; GSK35336023; GSK-35336023; GSK 35336023; EPZ-025654 HCl; EPZ-025654 hydrochloride

References

Drew AE, Moradei O, Jacques SL, Rioux N, Boriack-Sjodin AP, Allain C, Scott MP, Jin L, Raimondi A, Handler JL, Ott HM, Kruger RG, McCabe MT, Sneeringer C, Riera T, Shapiro G, Waters NJ, Mitchell LH, Duncan KW, Moyer MP, Copeland RA, Smith J, Chesworth R, Ribich SA. Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. Sci Rep. 2017 Dec 21;7(1):17993.

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