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PKM2 inhibitor 2825-0090
AOB13354
CAS: 313701-92-7
Chemical Name: 5-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid; 1-(3-Carboxy-4-hydroxy)phenyl-2,5-dimethylpyrrole
998 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $38.25 | Total: $191.25 |
| 1 | 10 | $32.40 | Total: $324.00 |
| 1 | 25 | $27.45 | Total: $686.25 |
| 1 | 50 | $23.40 | Total: $1,170.00 |
| 1 | 100 | $20.25 | Total: $2,025.00 |
Overview
Novel pyruvate kinase M2 (PKM2) inhibitor, reducing tumor growth of NSCLC xenografts in vivo
Chemical Properties
| Molecular Formula | C13H13NO3 |
| Molecular Weight | 231.25 |
| CAS Numbers | 313701-92-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 5-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid; 1-(3-Carboxy-4-hydroxy)phenyl-2,5-dimethylpyrrole |
| InChl Key | RPNDNUTUEQJRBE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/2C13H13NO3/c2*1-8-3-4-9(2)14(8)10-5-6-12(15)11(7-10)13(16)17/h2*3-7,15H,1-2H3,(H,16,17) |
| SMILES Code | O=C(O)C1=CC(N2C(C)=CC=C2C)=CC=C1O.CC3=CC=C(C)N3C4=CC=C(O)C(C(O)=O)=C4 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Pyruvate Kinase Inhibitor III
References
1) Zhou Y, et al.,. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2019 Oct 25. doi: 10.1002/ijc.32756. [Epub ahead of print] PubMed PMID: 31652354.
2) Zhou Q, Sun Y. MLN4924: additional activities beyond neddylation inhibition. Mol Cell Oncol. 2019 May 22;6(5):e1618174. doi: 10.1080/23723556.2019.1618174. eCollection 2019. PubMed PMID: 31528694; PubMed Central PMCID: PMC6736204.
