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MKT-077
AOB5068
CAS No:147366-41-4
Chemical Name: FJ-776; (2Z,5E)-3-ethyl-2-[(1-ethylpyridin-1-ium-2-yl)methylidene]-5-(3-methyl-1,3-benzothiazol-2-ylidene)-1,3-thiazolidin-4-one chloride
12994 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $12.75 | Total: $63.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 100 | $6.75 | Total: $675.00 |
Overview
Inhibitor of mitochondrial hsp70 family member, mortalin (mot-2), causing selective death of cancer cells
Chemical Properties
| Molecular Formula | C21H22ClM3OS2 |
| Molecular Weight | 432.0 |
| CAS Numbers | 147366-41-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium, monochloride |
| InChl Key | VSKYOTRJSLYFHX-UXJRWBAGSA-M |
| InChl Code | InChI=1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+; |
| SMILES Code | CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S3)=CC4=CC=CC=[N+]4CC)=O.[Cl-] |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
References
1) Li, X., Srinivasan, S.R., Connarn, J., et al. Analogs of the allosteric heat shock protein 70 (Hsp70) inhibitor, MKT-077, as anti-cancer agents. ACS Med.Chem.Lett. 4(11), (2013).
2) Rousaki, A., Miyata, Y., Jinwal, U.K., et al. Allosteric drugs: The interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of Molecular Biology 411(3), 614-632 (2011).
3) Wadhwa, R., Sugihara, T., Yoshida, A., et al. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Research 60(24), 6818-6821 (2000).
