DPM-1001

DPM-1001

AOB33273

CAS No: 1471172-27-6

 

Chemical Name: Methyl (3β,7α)-3-((4-((pyridin-2-ylmethyl)amino)butyl)amino)-7-hydroxycholan-24-oate

More details

574 Items

$102.70

$102.70 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $67.15 Total: $335.75
110 $56.88 Total: $568.80
125 $48.19 Total: $1,204.75
150 $41.08 Total: $2,054.00
1100 $35.55 Total: $3,555.00

Overview

Novel potent, specific, non-competitive, and orally bioavailable inhibitor of PTP1B, displaying antidiabetic properties associated with enhanced signaling through insulin and leptin receptors in animal models of diet-induced obesity

Chemical Properties

Molecular FormulaC35H57N3O3
Molecular Weight567.86
CAS Numbers1471172-27-6
SolubilityDMSO
Purity 99% (HPLC)
IUPAC/Chemical NameMethyl (3β,7α)-3-((4-((pyridin-2-ylmethyl)amino)butyl)amino)-7-hydroxycholan-24-oate
InChl KeyRVANDQULNPITCN-DHKCSNTESA-N
InChl CodeInChI=1S/C35H57N3O3/c1-24(10-13-32(40)41-4)28-11-12-29-33-30(15-17-35(28,29)3)34(2)16-14-26(21-25(34)22-31(33)39)37-20-8-7-18-36-23-27-9-5-6-19-38-27/h5-6,9,19,24-26,28-31,33,36-37,39H,7-8,10-18,20-23H2,1-4H3/t24-,25?,26+,28-,29+,30+,31-,33+,34+,35-/m1/s1
SMILES CodeC[C@H](CCC(OC)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)CC4C[C@@H](NCCCCNCC5=NC=CC=C5)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

DPM-1001; DPM1001; DPM 1001

References

1) Krishnan N, Felice C, Rivera K, Pappin DJ, Tonks NK. DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease. Genes Dev. 2018 Jul 1;32(13-14):944-952.

2) Krishnan N, Konidaris KF, Gasser G, Tonks NK. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525

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