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TCH-165
AOB36330
CAS: 1446350-60-2
Chemical Name: Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate
1992 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $17.85 | Total: $89.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 100 | $9.45 | Total: $945.00 |
Overview
Novel modulator of proteasome assembly, resulting in an increase in 20S levels
Chemical Properties
| Molecular Formula | C39H37N3O3 |
| Molecular Weight | 595.74 |
| CAS Numbers | 1446350-60-2 |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | Ethyl (4S,5S)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate |
| InChl Key | XXDLWRCUPASJGY-VQIIKMDRSA-N |
| InChl Code | InChI=1S/C39H37N3O3/c1-3-45-38(43)39(33-17-11-6-12-18-33)36(31-19-23-34(24-20-31)40-27-29-13-7-4-8-14-29)42(28-30-15-9-5-10-16-30)37(41-39)32-21-25-35(44-2)26-22-32/h4-26,36,40H,3,27-28H2,1-2H3/t36-,39-/m0/s1 |
| SMILES Code | O=C([C@@]1(C2=CC=CC=C2)N=C(C3=CC=C(OC)C=C3)N(CC4=CC=CC=C4)[C@H]1C5=CC=C(NCC6=CC=CC=C6)C=C5)OCC |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
TCH165; TCH 165; TCH-165
References
1) Njomen E, Osmulski PA, Jones CL, Gaczynska M, Tepe JJ. Small Molecule Modulation of Proteasome Assembly. Biochemistry. 2018 Jul 17;57(28):4214-4224. doi: 10.1021/acs.biochem.8b00579. Epub 2018 Jun 27. PubMed PMID: 29897236; PubMed Central PMCID: PMC6241286.
