MK-8722

Name: MK-8722
Brand: AOBIOUS
SKU: AOB33226
Price: 17 USD
Availability: InStock

Cat No: AOB33226

Condition

CAS: 1394371-71-1

Chemical Name: (3R,3aR,6R,6aR)-6-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

AOBIOUS launched this product in 2018

CITATIONS - Publications That Use AOBIOUS Product

1) Bioeng Transl Med. 2021 Jan; 6(1): e10187.

2) Biochem J (2022) 479 (11): 1181–1204.

3) Cell Reports V38 (1) 110197 (2022)

4) BioRxiv (2021)

More details

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$14.45	Total: $72.25
1	10	$12.24	Total: $122.40
1	25	$10.37	Total: $259.25
1	50	$8.84	Total: $442.00
1	100	$7.65	Total: $765.00

Overview

Novel Systemic pan-AMPK activator, improving glucose homeostasis but inducing cardiac hypertrophy

Chemical Properties

Molecular Formula	C24H20ClN3O4
Molecular Weight	449.89
CAS Numbers	1394371-71-1
Solubility	DMSO
Purity	98% by HPLC
IUPAC/Chemical Name	(3R,3aR,6R,6aR)-6-((6-([1,1'-biphenyl]-4-yl)-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol
InChl Key	VEGCGBKTFKSLJB-MCEIDBOGSA-N
InChl Code	InChI=1S/C24H20ClN3O4/c25-19-16(15-8-6-14(7-9-15)13-4-2-1-3-5-13)10-26-23-20(19)27-24(28-23)32-18-12-31-21-17(29)11-30-22(18)21/h1-10,17-18,21-22,29H,11-12H2,(H,26,27,28)/t17-,18-,21-,22-/m1/s1
SMILES Code	ClC1=C2C(NC(O[C@@H]3CO[C@@]4([H])[C@]3([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C(C6=CC=CC=C6)C=C5

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

MK-8722; MK 8722; MK8722

References

1) Weihrauch M, etc. Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochem Pharmacol. 2017 Oct 20. pii: S0006-2952(17)30636-6.

2) Myers RW, etc. Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy. Science. 2017 Aug 4;357(6350):507-511.

3) Danqing Feng, etc. Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase Publication Date (Web): December 1, 2017 (Letter)