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DI-591
AOB37880
CAS No: 2245887-38-9
Chemical Name: (S)-N-((S)-1-Cyclohexyl-2-(3-morpholinopropanamido)ethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide
840 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $45.05 | Total: $225.25 |
| 1 | 10 | $38.16 | Total: $381.60 |
| 1 | 25 | $32.33 | Total: $808.25 |
| 1 | 50 | $27.56 | Total: $1,378.00 |
| 1 | 100 | $23.85 | Total: $2,385.00 |
Overview
Novel high-affinity, cell-permeable inhibitor of the DCN1-UBC12 interaction, selectively blocking cullin 3 neddylation
Chemical Properties
| Molecular Formula | C37H47N5O4S |
| Molecular Weight | 585.81 |
| CAS Numbers | 2245887-38-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (S)-N-((S)-1-Cyclohexyl-2-(3-morpholinopropanamido)ethyl)-3-(6-isopropylbenzo[d]thiazol-2-yl)-2-propionamidopropanamide |
| InChl Key | CNJKDQGPBAWNRY-IZZNHLLZSA-N |
| InChl Code | InChI=1S/C31H47N5O4S/c1-4-28(37)33-25(19-30-34-24-11-10-23(21(2)3)18-27(24)41-30)31(39)35-26(22-8-6-5-7-9-22)20-32-29(38)12-13-36-14-16-40-17-15-36/h10-11,18,21-22,25-26H,4-9,12-17,19-20H2,1-3H3,(H,32,38)(H,33,37)(H,35,39)/t25-,26+/m0/s1 |
| SMILES Code | O=C(N[C@@H](C1CCCCC1)CNC(CCN2CCOCC2)=O)[C@@H](NC(CC)=O)CC3=NC4=CC=C(C(C)C)C=C4S3 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
DI-591; DI591; DI 591
References
Zhou H, Lu J, Liu L, Bernard D, Yang CY, Fernandez-Salas E, Chinnaswamy K, Layton S, Stuckey J, Yu Q, Zhou W, Pan Z, Sun Y, Wang S. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nat Commun. 2017 Oct 27;8(1):1150.
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