HTH-02-006

Name: HTH-02-006
Brand: AOBIOUS
SKU: AOB36960
Price: 129 USD
Availability: InStock

Cat No: AOB36960

Condition

CAS: N/A

Chemical Name: N-(3-((5-Iodo-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide

More details

1652 Item Items

Print Quotation

Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$109.65	Total: $548.25
1	10	$92.88	Total: $928.80
1	25	$78.69	Total: $1,967.25
1	50	$67.08	Total: $3,354.00
1	100	$58.05	Total: $5,805.00

Overview

Novel semispecific NUAK2 inhibitor, reducing levels of phosphorylated MYPT1 in HuCCT-1 cells indicating its activity on NUAK2 and/or NUAK1, which can also phosphorylate MYPT1

Chemical Properties

Molecular Formula	C25H29IN6O3
Molecular Weight	588.45
Solubility	DMSO
Purity	98% by HPLC
IUPAC/Chemical Name	N-(3-((5-iodo-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin4-yl)oxy)phenyl)propionamide
InChl Key	KQMWYEJQANQTDM-UHFFFAOYSA-N
InChl Code	InChI=1S/C25H29IN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)
SMILES Code	IC1=CN=C(NC2=C(OC)C=C(N3CCN(C)CC3)C=C2)N=C1OC4=CC=CC(NC(CC)=O)=C4

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

HTH-02-006; HTH02006; HTH 02 006; HTH-02006; HTH 02006; HTH02006;

References

1) Dey A, Varelas X, Guan KL. (2020) Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov, 19 (7): 480-494. [PMID:32555376]

2) Juan WC, Hong W. (2016) Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy. Genes (Basel), 7 (9). [PMID:27589805]

3) Yuan WC, Pepe-Mooney B, Galli GG, Dill MT, Huang HT, Hao M, Wang Y, Liang H, Calogero RA, Camargo FD. (2018) NUAK2 is a critical YAP target in liver cancer. Nat Commun, 9 (1): 4834. [PMID:30446657]