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Verteporfin
AOB5623
CAS No:129497-78-5
AOBIOUS launched this product in 2016
CITATIONS - Publications That Use AOBIOUS Product
282 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $19.55 | Total: $97.75 |
| 1 | 10 | $16.56 | Total: $165.60 |
| 1 | 25 | $14.03 | Total: $350.75 |
| 1 | 50 | $11.96 | Total: $598.00 |
| 1 | 100 | $10.35 | Total: $1,035.00 |
Overview
YAP inhibitor; disrupting YAP-TEAD interactions and enhancing trypsin cleavage of YAP
Chemical Properties
| Molecular Formula | C41H42N4O8 |
| Molecular Weight | 718.79 |
| CAS Numbers | 129497-78-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3-[(23S,24R)-14-ethenyl-5-(3-methoxy-3-oxopropyl)-22,23-bis(methoxycarbonyl)-4,10,15,24-tetramethyl-25,26,27,28-tetraazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1,3,5,7,9,11(27),12,14,16,18(25),19,21-dodecaen-9-yl]propanoic acid |
| InChl Key | YTZALCGQUPRCGW-MXVXOLGGSA-N |
| InChl Code | InChI=1S/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)25(12-15-37(48)51-6)33(44-30)18-32-24(11-14-36(46)47)21(3)28(43-32)16-31(23)42-29/h9-10,13,16-19,38,42,44H,1,11-12,14-15H2,2-8H3,(H,46,47)/b28-16-,29-17-,30-19-,31-16-,32-18-,33-18-,34-17-,35-19-/t38-,41+/m0/s1 |
| SMILES Code | O=C(O)CCC1=C(C)C(/C=C2C(C=C)=C(C)/C(N/2)=C/3)=N/C1=CC(N4)=C(CCC(OC)=O)C(C)=C4/C=C5[C@]6(C)[C@H](C(OC)=O)C(C(OC)=O)=CC=C6C3=N/5 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
DB00460, CL 318952, BPD-MA, BpdMA, Benzoporphyrin D, Benzoporphyrin derivative monoacid ring A, Verteporfin, Visudyne.
References
1) Karim SP, Adelman RA. Profile of verteporfin and its potential for the treatment of central serous chorioretinopathy. Clin Ophthalmol. 2013;7:1867-75. doi: 10.2147/OPTH.S32177. Epub 2013 Sep 19. Review. PubMed PMID: 24092965; PubMed Central PMCID: PMC3788817.
2) Ziemssen F, Heimann H. Evaluation of verteporfin pharmakokinetics--redefining the need of photosensitizers in ophthalmology. Expert Opin Drug Metab Toxicol. 2012 Aug;8(8):1023-41.
