UAMC-1110

UAMC-1110

AOB17689

CAS: 1448440-52-5.

Chemical Name: SP-13786; (S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide

More details

1823 Items

$15.00

$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $12.75 Total: $63.75
110 $10.80 Total: $108.00
125 $9.15 Total: $228.75
150 $7.80 Total: $390.00
1100 $6.75 Total: $675.00

Overview

Novel potent and selective inhibitor of fibroblast activation protein (FAP), displaying low nanomolar inhibitory potency and high selectivity against the related dipeptidyl peptidases (DPPs) DPPIV, DPP9, DPPII, and prolyl oligopeptidase (PREP)

Chemical Properties

Molecular FormulaC17H14F2N4O2
Molecular Weight344.32
CAS Numbers1448440-52-5
SolubilityDMSO and Alcohol
Purity98% by HPLC
IUPAC/Chemical Name (S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
InChl KeyPUOOCZVRHBHJRS-NSHDSACASA-N
InChl CodeInChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1
SMILES CodeO=C(C1=CC=NC2=CC=CC=C12)NCC(N3[C@H](C#N)CC(F)(F)C3)=O

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

UAMC-1110; UAMC 1110; UAMC1110; SP-13786; SP 13786; SP13786;

References

Gunderson AJ, Yamazaki T, McCarty K, Phillips M, Alice A, Bambina S, Zebertavage L, Friedman D, Cottam B, Newell P, Gough MJ, Crittenden MR, Van der Veken P, Young KH. Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma. PLoS One. 2019 Feb 6;14(2):e0211117. doi: 10.1371/journal.pone.0211117. eCollection 2019. PubMed PMID: 30726287; PubMed Central PMCID: PMC6364920.

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